منابع مشابه
Development of new antidepressants
The development of the first effective antidepressants in the late 1950s marked a turning point in the treatment of depressive illness. In 1957 the monoamine oxidase inhibitor (MAOI) iproniazid was discovered by chance, while searching for new antituberculous drugs. One year later the tricyclic antidepressant (TCA) imipramine was introduced, having been developed originally as an antipsychotic....
متن کاملContribution of sleep research to the development of new antidepressants
Several sleep anomalies are known to accompany depression and other psychiatric disorders, and to be partially modified by drugs efficient on clinical symptoms. Many puzzling theoretical questions remain, even after 30 years of research, because these drugs do not act in a uniform way: some reduce slow-wave sleep while others increase it some prolong rapid-eye movement sleep latency, while othe...
متن کاملBeyond Ketamine: New Approaches to the Development of Safer Antidepressants
BACKGROUND Ketamine has been reported to exert rapid and sustained antidepressant effects in patients with depression, including patients with treatment-resistant depression. However, ketamine has several drawbacks such as psychotomimetic/dissociative symptoms, abuse potential and neurotoxicity, all of which prevent its routine use in daily clinical practice. METHODS Therefore, development of...
متن کاملnew generation of antidepressants in pregnant women
although pregnancy was once thought to protect against psychiatric disorders, gravid and non gravid women have similar risks for major depression, at 10% to 15%. both depression and antidepressant treatment during pregnancy have been associated with risks. few medications have been proved unequivocally safe during pregnancy. although certain antidepressants have not been linked with an increase...
متن کاملNew antidepressants in pregnancy.
QUESTION I have read that fluoxetine is the drug of choice for treating depression during pregnancy. One of my patients, who did not respond to the "old" selective serotonin reuptake inhibitors, is doing well on venlafaxine and is now 6 weeks pregnant. What advice should I give her? ANSWER Fluoxetine is recommended because to date it has the most evidence of its safety. It is important that w...
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ژورنال
عنوان ژورنال: Advances in Psychiatric Treatment
سال: 1997
ISSN: 1355-5146,1472-1481
DOI: 10.1192/apt.3.1.46